Reduced hepatotoxicity by total glucosides of paeony in combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis

► We report hepatoprotective role of TGP in RA treated with MTX and LEF. ► We examine the additive role of TGP with MTX and LEF. ► TGP add on therapy may show promise in the treatment of RA.