Time-dependent effect of in vivo inflammation on eicosanoid and endocannabinoid levels in plasma, liver, ileum and adipose tissue in C57BL/6 mice fed a fish-oil diet

►Effect of inflammation on eicosanoids and endocannabinoids is investigated in detail. ►Time- and tissue-dependent effects were observed for eicosanoids and endocannabinoids. ►Distinct effects were observed for n-3 fatty acid- and CYP-derived eicosanoids. ►Effects in plasma were not similar to effects in tissues. ►Analyzing eicosanoid and endocannabinoid profiles in the plasma and tissues is important.