Antitumor effects and chemical compositions of Eupolyphaga sinensis Walker ethanol extract

Eupolyphaga sinensis Walker ethanol extract (ESEE) contains high amounts of saturated and polyunsaturated fatty acids. Oral administration of ESEE could inhibit tumor growth, promote TNF-α and IFN-γ productions, and induce apoptosis of hepatocarcinoma via increase of Bax/Bcl-2 ratio and activation of caspases-3.