کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5838845 | 1123981 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells
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کلمات کلیدی
CFU-ECFU-GMCFU-GEMMPOASGSHWBCCSFsBFU-EUCBNF-kappa BGM-CSFNPSHgranulocyte/macrophage colony-stimulating factor - granulocyte / ماکروفاژ عامل کلونی تحریک کنندهROS - ROSinterleukin - اینترلوکینtumor necrosis factor α - تومور نکروز عامل αUmbilical cord blood - خون بند نافSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازTNF-α - فاکتور نکروز توموری آلفاnuclear factor kappa B - فاکتور هسته ای کاپا BLeukocytes - لکوسیتNeutrophils - نوتروفیل هاNon-protein thiols - پروتئین غیر پروتئینیCat's claw - پنجه گربهwhite blood cell - گلبول سفید خونGlutathione - گلوتاتیونReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
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چکیده انگلیسی
Ethnopharmacological relevanceThe Asháninkas, indigenous people of Peru, use cat's claw (Uncaria tomentosa) to restore health. Uncaria tomentosa has antioxidant activity and works as an agent to repair DNA damage. It causes different effects on cell proliferation depending on the cell type involved; specifically, it can stimulate the proliferation of myeloid progenitors and cause apoptosis of neoplastic cells. Neutropenia is the most common collateral effect of chemotherapy. For patients undergoing cancer treatment, the administration of a drug that stimulates the proliferation of healthy hematopoietic tissue cells is very desirable.It is important to assess the acute effects of Uncaria tomentosa on granulocyte-macrophage colony-forming cells (CFU-GM) and in the recovery of neutrophils after chemotherapy-induced neutropenia, by establishing the correlation with filgrastim (rhG-CSF) treatment to evaluate its possible use in clinical oncology.Materials and methodsThe in vivo assay was performed in ifosfamide-treated mice receiving oral doses of 5 and 15 mg of Uncaria tomentosa and intraperitoneal doses of 3 and 9 μg of filgrastim, respectively, for four days. Colony-forming cell (CFC) assays were performed with human hematopoietic stem/precursor cells (hHSPCs) obtained from umbilical cord blood (UCB).ResultsBioassays showed that treatment with Uncaria tomentosa significantly increased the neutrophil count, and a potency of 85.2% was calculated in relation to filgrastim at the corresponding doses tested. An in vitro CFC assay showed an increase in CFU-GM size and mixed colonies (CFU-GEMM) size at the final concentrations of 100 and 200 μg extract/mL.ConclusionsAt the tested doses, Uncaria tomentosa had a positive effect on myeloid progenitor number and is promising for use with chemotherapy to minimize the adverse effects of this treatment. These results support the belief of the Asháninkas, who have classified Uncaria tomentosa as a 'powerful plant'.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 137, Issue 1, 1 September 2011, Pages 856-863
Journal: Journal of Ethnopharmacology - Volume 137, Issue 1, 1 September 2011, Pages 856-863
نویسندگان
Iria Farias, Maria do Carmo Araújo, Estevan Sonego Zimmermann, Sergio Luiz Dalmora, Aloisio Luiz Benedetti, Marcio Alvarez-Silva, Ana Carolina Cavazzin Asbahr, Gustavo Bertol, Júlia Farias, Maria Rosa Chitolina Schetinger,