کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5839671 | 1123997 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Realgar and realgar-containing Liu-Shen-Wan are less acutely toxic than arsenite and arsenate
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کلمات کلیدی
MT-1RealgarHO-1LSWRT-PCRALTHeme oxygenase-1Arsenate - آرسناتarsenite - آرسنیتAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST BUN - خوبCAM - ساخت به کمک کامپیوترAcute toxicity - سمیت حادcomplementary and alternative medicine - طب مکمل و جایگزینMetallothionein-1 - متالوتیونیین-1blood urea nitrogen - نیتروژن اوره خونreverse transcription polymerase chain reaction - واکنش زنجیره ای پلیمراز رونویسی معکوس
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ethnopharmacological relevanceLiu-Shen-Wan (LSW) is a widely-used traditional Chinese medicine containing realgar (As4S4).Aim of the StudyRealgar has been included in many traditional medicines, and is often taken as arsenite for risk assessment in realgar-containing traditional remedies. Is realgar toxicologically similar to arsenite?Materials and MethodMice were orally given LSW (60 and 200Â mg/kg; 200Â mg LSW contains 27Â mg realgar), realgar (30Â mg/kg, equivalent to 21Â mg As/kg), and the equivalent As dose as sodium arsenite (NaAsO2), or as arsenate (Na2HAsO4). Acute toxicity and tissue As accumulation were determined 8Â h later.ResultsArsenite and arsenate increased serum alanine aminotransferase (ALT) levels, indicative of liver injury; blood urea nitrogen (BUN) was also increased by arsenite and arsenate, indicative of nephrotoxicity. No elevations of ALT and BUN were observed in LSW and realgar groups. Histopathology showed more damage in arsenite- and arsenate-treated liver and kidneys, while in realgar- and LSW- treated animals, only mild alterations were seen. Hepatic and renal As contents were dramatically increased to 6200 and 3350Â ng/g, respectively, after arsenite, but only increased to 260 and 180Â ng/g after LSW. The expressions of arsenic-sensitive stress genes, namely metallothionein-1 and heme oxygenase-1, were increased after arsenite or arsenate by 3-10-folds, but were unaltered after LWS and realgar.ConclusionsRealgar and LSW are much less toxic than arsenite and arenate. The use of total As content to evaluate the safety of realgar-containing traditional medicines is not scientifically sound.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Ethnopharmacology - Volume 134, Issue 1, 8 March 2011, Pages 26-31
Journal: Journal of Ethnopharmacology - Volume 134, Issue 1, 8 March 2011, Pages 26-31
نویسندگان
Jie Liu, Shi-Xia Liang, Yuan-Fu Lu, Jia-Wei Miao, Qin Wu, Jing-Shan Shi,