ATP releases ATP or other nucleotides from human peripheral blood leukocytes through purinergic P2 receptors

500 μM ATP induced the release of ATP or other nucleotides through activation of P2Y2,4,6,11 receptors in human leukocytes, and probably via P2X receptors at higher concentrations. This ATP-induced nucleotides release constitutes a potential mechanism leading to amplification of ATP signaling.