Endothelin-1 plasma levels and vascular endothelial dysfunction in primary open angle glaucoma

The increase of ET-1 in POAG patients is related to vascular dysfunction (r = 0.942; p = 0.001) and vascular dysfunction is related to sub-clinical intraocular inflammation (r = 0.968; p = 0.001). Thus ET-1 and vascular dysfunction related to sub-clinical inflammation may play a key role in determining a progressive visual field damage in POAG patients who present a well-controlled IOP.