کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5842653 | 1124765 | 2013 | 7 صفحه PDF | دانلود رایگان |
AimsWe previously reported that mechanical atrial stretch (AS) by balloon distention increased gastric tonus in anesthetized rats. The present study evaluated the effect of AS on the gastric emptying of a liquid test meal in awake rats and its underlying neural mechanisms.Main methodsAnesthetized male rats received a balloon catheter into the right atrium and a gastrostomy cannula. The next day, mean arterial pressure (MAP), heart rate (HR), central venous pressure (CVP), and cardiac output (CO) were continuously monitored. After the first 20 min of monitoring (basal interval), the balloon was either distended or not (control) with 30, 50, or 70 μl saline for 5 min. Fifteen minutes later, the rats received the test meal (glucose solution with phenol red), and fractional gastric dye retention was determined 10, 20, or 30 min later.Key findingsHeart rate and CVP values were transiently increased by 50 or 70 μl AS but not 30 μl AS, whereas gastric emptying was slower after 30, 50, or 70 μl AS than after sham distention. Subdiaphragmatic vagotomy or splanchnicotomy + celiac ganglionectomy and capsaicin, ondansetron, hexamethonium, L-NAME, and glibenclamide treatment prevented the AS-induced delay in gastric emptying, whereas atropine and guanethidine treatment failed to prevent it.SignificanceAtrial stretch inhibited the gastric emptying of liquid via non-adrenergic and non-cholinergic pathways that activate nitric oxide-K+ATP channels.
Journal: Life Sciences - Volume 92, Issue 10, 21 March 2013, Pages 569-575