Hydrogen sulfide regulates cardiac sarcoplasmic reticulum Ca2Â + uptake via KATP channel and PI3K/Akt pathway

Endogenous H2S transiently and reversibly inhibits SR Ca2 + uptake in rat heart SR because of downregulated SERCA activity associated with PLB phosphorylation by the PI3K/Akt or KATP channel. The transient negative regulation of SR Ca2 + uptake and the L-type Ca2 + channel contributes to Ca2 + cycle homeostasis, which might be an important molecular mechanism in ischemic diseases.