Exercise training has beneficial anti-atrophy effects by inhibiting oxidative stress-induced MuRF1 upregulation in rats with diabetes

► Exercise training diminished the skeletal muscle wasting in diabetic rats. ► Exercise training decreased oxidative stress and inhibited MuRF1 expression in diabetic rats. ► Oxidative stress-induced MuRF1 upregulation promoted proteasome dependent degradation of MHC in myotubes. ► Anti-atrophy effects of exercise on diabetes is mediated by downregulating MuRF1 and preventing the degradation ofMHC.