کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5843382 | 1560866 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients
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کلمات کلیدی
GSK-3βCREB1Bipolar Disorder Type IFLT1IL2RACCNA1BDIDSM-IVcyclin A1LiClSYN2RMAIGF-1IGFR1SADS-LqRT-PCRHLA-DQB1Synapsin IIPLD1LCLSMAPK3mitogen-activated protein kinase 3FDRBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز MAPK - MAPKPI3K/AKT - PI3K / AKTbipolar disorder - اختلال دو قطبیEBV - اپشتین بار ویروسfold change - تغییر در برابرlymphoblastoid cell lines - خطوط سلول لنفوبلاستوئیدKEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو Kyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوDiagnostic and Statistical Manual of Mental Disorders IV - راهنمای تشخیصی و آماری اختلالات روانی IVRdc - طبقه همکفbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استLymphoblasts - لنفوبلاست هاlithium chloride - لیتیم کلریدRobust multi-array average - متوسط چند آرایه قویResearch diagnostic criteria - معیارهای تشخیصی پژوهشfalse discovery rate - میزان کشف کاذبquantitative real-time PCR - واکنش زنجیره ای پلیمراز واقعی در زمان واقعیEpstein–Barr virus - ویروس Epstein-Barrresponders - پاسخ دهندگانLithium response - پاسخ لیتیمGlycogen synthase kinase 3-β - گلیکوزین سیتستاز کیناز 3-β
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients](/preview/png/5843382.png)
چکیده انگلیسی
Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change = 1.94; p = 0.005; sample 2, fold change = 2.21; p = 0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 73, July 2013, Pages 1-7
Journal: Pharmacological Research - Volume 73, July 2013, Pages 1-7
نویسندگان
Alessio Squassina, Marta Costa, Donatella Congiu, Mirko Manchia, Andrea Angius, Valeria Deiana, Raffaella Ardau, Caterina Chillotti, Giovanni Severino, Stefano Calza, Maria Del Zompo,