کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844078 | 1127528 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacotherapy of autonomic failure
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کلمات کلیدی
GCIMSAPPHMultiple system atrophy - آتروفی سیستم چندگانهParkinson's disease - بیماری پارکینسونTreatment - درمانAutonomic failure - شکست حادPharmacology - فارماکولوژی یا داروشناسیPure autonomic failure - نقص اتونوم خالصPAF - نیروی هوایی پاکستانOrthostatic hypotension - هیپوتانسیون ارتواستاتیک، کاهش فشار خون وضعیتیDAN - و
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pharmacotherapy of autonomic failure Pharmacotherapy of autonomic failure](/preview/png/5844078.png)
چکیده انگلیسی
The clinical picture of autonomic failure is characterized by severe and disabling orthostatic hypotension. These disorders can develop as a result of damage of central neural pathways or peripheral autonomic nerves, caused either by a primary autonomic neurodegenerative disorder or secondary to systemic illness. Treatment should be focused on decreasing pre-syncopal symptoms instead of achieving blood pressure goals. Non-pharmacologic strategies such as physical counter-maneuvers, dietary changes (i.e. high salt diet, rapid water drinking or compression garments) are the first line therapy. Affected patients should be screened for co-morbid conditions such as post-prandial hypotension and supine hypertension that can worsen orthostatic hypotension if not treated. If symptoms are not controlled with these conservative measures the next step is to start pharmacological agents; these interventions should be aimed at increasing intravascular volume either by promoting water and salt retention (fludrocortisone) or by increasing red blood cell mass when anemia is present (recombinant erythropoietin). When pressor agents are needed, direct pressor agents (midodrine) or agents that potentiate sympathetic activity (atomoxetine, yohimbine, pyridostigmine) can be used. It is preferable to use short-acting pressor agents that can be taken on as needed basis in preparation for upright activities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 134, Issue 3, June 2012, Pages 279-286
Journal: Pharmacology & Therapeutics - Volume 134, Issue 3, June 2012, Pages 279-286
نویسندگان
Cyndya Shibao, Luis Okamoto, Italo Biaggioni,