کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844306 | 1561027 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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![عکس صفحه اول مقاله: N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats](/preview/png/5844306.png)
چکیده انگلیسی
Kindling is a form of behavioral sensitization that is related to the progression of several neuropsychiatric disorders such as bipolar disorder. We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC) against NIC-kindling in female periadolescent rats. To do this female Wistar rats at postnatal day 30 received repeated injections of NIC 2Â mg/kg, i.p. every weekday for up to 19Â days. NAC90, 180 or 270Â mg/kg, i.p. was administered 30Â min before NIC. The levels of glutathione (GSH), superoxide dismutase (SOD) activity, lipid peroxidation (LP) and nitrite were determined in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). The development of kindling occurred at a median time of 16.5Â days with 87.5% of NIC animals presenting stage 5 seizures in the last day of drug administration. NAC270 prevented the occurrence of kindling. NIC-kindled animals presented decreased levels of GSH and increased LP in the PFC, HC and ST, while SOD activity was decreased in the ST. NAC180 or 270 prevented the alterations in GSH induced by NIC, but only NAC270 prevented the alterations in LP. Nitrite levels increased in the ST of NAC270 pretreated NIC-kindled animals. Taken together we demonstrated that NAC presents anti-kindling effects in female animals partially through the restoration of oxidative alterations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 67, 3 June 2016, Pages 58-65
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 67, 3 June 2016, Pages 58-65
نویسندگان
Adriana Mary Nunes Costa Okamura, PatrÃcia Xavier L. Gomes, Gersilene V. de Oliveira, Fernanda Yvelize R. de Araújo, Viviane S. Tomaz, Adriano José Maia Chaves Filho, Francisca Cléa F. de Sousa, Silvânia Maria Mendes Vasconcelos,