کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844472 | 1561044 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preliminary findings of the effects of rivastigmine, an acetylcholinesterase inhibitor, on working memory in cocaine-dependent volunteers
ترجمه فارسی عنوان
یافته های مقدماتی اثرات ریواستیگمین، مهار کننده استیل های شلینستراز، بر حافظه کاری داوطلبان وابسته به کوکائین
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MEDVAMCBuChEbutyrylcholinesteraseM.I.N.I.CPT-IIWAIS-IIIDSM-IVACh - آهAChE - آهیAcetylcholine - استیل کولینAcetylcholinesterase - استیل کولین استرازWorking memory - حافظه فعال یا حافظه کاریtwice daily - دو بار در روزRivastigmine - ریواستیگمینNeurocognition - شناخت عصبیMini-International Neuropsychiatric Interview - مصاحبه نور بین الملل مینی بین المللیacetylcholinesterase inhibitor - مهارکننده استیل کولین استرازBID - پیشنهادCocaine - کوکائین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Long-term cocaine use is a risk factor for the onset of neurocognitive impairment. This study sought to determine whether the cholinesterase inhibitor rivastigmine could improve neurocognitive performance in cocaine-dependent individuals. Cocaine-dependent individuals who were not seeking treatment at the time of enrollment in the study were randomly assigned to receive placebo (n = 16), rivastigmine 3 mg (n = 13), or rivastigmine 6 mg (n = 12). The baseline neurocognitive assessment, which included measures of attention/information processing (as measured by the Continuous Performance Task-II (CPT-II)), verbal learning/episodic memory (as measured by the Hopkins Verbal Learning Test-Revised (HVLT-R)), and working memory (as measured by the Dual N-Back Task), was conducted prior to the administration of study medication (Day 0). The follow-up assessment was conducted on Day 8 after the participants had received rivastigmine or placebo for 7 days (Day 2-8). Rivastigmine administration significantly improved performance on one measure of working memory span (mean n-back span). This study provides additional data showing that cocaine-associated neurocognitive impairment, specifically working memory deficits, can be remediated, at least to some degree.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 50, 3 April 2014, Pages 137-142
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 50, 3 April 2014, Pages 137-142
نویسندگان
James J. III, Ari D. Kalechstein, Christopher D. Verrico, Nicholas M. Arnoudse, Benjamin A. Shapiro, Richard II,