کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844497 | 1561046 | 2014 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Network beyond IDO in psychiatric disorders: Revisiting neurodegeneration hypothesis
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کلمات کلیدی
BCG5HIAAaMCCACCHAAHAAOAFMK5-hydroxyindole acetic acid - 5-hydroxyindole اسید استیکAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPACh - آهAttention deficit hyperactive disorder - اختلال بیش فعالی کمبود توجهAcetylcholine - استیل کولین3-Hydroxyanthranilic acid - اسید 3-هیدروکسی سنترانلیلیکgamma-aminobutyric acid - اسید گاما آمینو بوتیریکBacille Calmette-Guérin - باسی کالمت گینهADHD - بیشفعالیDopamine - دوپامینBBB - سد خونی مغزیanterior cingulate cortex - قشر سینگولیت قدامی، کورتکس سینگولیت قدامیblood-brain-barrier - مانع خون مغزیCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The involvement of immune system activation in the pathophysiology of certain psychiatric disorders is well documented. Inflammatory molecules such as pro-inflammatory cytokines could enhance the activity of the indoleamine 2,3-dioxygenase (IDO) enzyme which is the first rate-limiting enzyme of the tryptophan degradation pathway, the kynurenine pathway. The increased tryptophan degradation could induce serotonin depletion and depressive mood. On the other hand, the downstream metabolites from this pathway, such as 3-hydroxykynurenine, quinolinic acid and kynurenic acid, are neuroactive metabolites which can modulate several neurotransmissions, such as glutamatergic, GABAergic, dopaminergic and noradrenergic neurotransmissions, which in turn induce changes in neuronal-glial network and neuropsychiatric consequences. In this issue, we have revised the previous 'neurodegeneration hypothesis,' which explained the involvement of cytokines and IDO pathway interaction in depression, with a further extended view related to the network beyond IDO, the network between immune molecules, tryptophan metabolites and different neurotransmitters, in depression and other major psychiatric disorders such as schizophrenia, bipolar disorder and childhood psychiatric disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 48, 3 January 2014, Pages 304-313
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 48, 3 January 2014, Pages 304-313
نویسندگان
Aye-Mu Myint, Yong-Ku Kim,