کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5844506 1561046 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correspondence of executive function related functional and anatomical alterations in aging brain
ترجمه فارسی عنوان
پیوند عملکرد تابع اجرایی و تغییرات آناتومیکی مرتبط در مغز سالمند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


- A series of meta-analyses were conducted to study age related brain alterations.
- Functional alterations related to executive function were examined.
- Anatomical reductions and relative preservations of gray matter were examined.
- Only hyperactivations and gray matter reductions overlapped in the bilateral DLPFC.

Neurocognitive aging studies have focused on age-related changes in neural activity or neural structure but few studies have focused on relationships between the two. The present study quantitatively reviewed 24 studies of age-related changes in fMRI activation across a broad spectrum of executive function tasks using activation likelihood estimation (ALE) and 22 separate studies of age-related changes in gray matter using voxel-based morphometry (VBM). Conjunction analyses between functional and structural alteration maps were constructed. Overlaps were only observed in the conjunction of dorsolateral prefrontal cortex (DLPFC) gray matter reduction and functional hyperactivation but not hypoactivation. It was not evident that the conjunctions between gray matter and activation were related to task performance. Theoretical implications of these results are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 48, 3 January 2014, Pages 41-50
نویسندگان
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