Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder

► GABA-edited MRS was used to study GABA levels in ACC/mPFC and OCC in panic patients. ► A GABA deficit was found in the ACC/mPFC of panic disorder patients. ► No other significant metabolic changes were found in either brain region. ► Patients with positive family history tend to have a more pronounced GABA deficit.