کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5844668 1561048 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in mice
چکیده انگلیسی


- CBD could have beneficial effects on motor related striatal disorders.
- We observed that CBD attenuated the catalepsy caused by different mechanisms.
- The anticataleptic effects of CBD were blocked by a 5-HT1A receptor antagonist.

Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa plant that produces antipsychotic effects in rodents and humans. It also reverses L-dopa-induced psychotic symptoms and improves motor function in Parkinson's patients. This latter effect raised the possibility that CBD could have beneficial effects on motor related striatal disorders. To investigate this possibility we evaluated if CBD would prevent catalepsy induced by drugs with distinct pharmacological mechanisms. The catalepsy test is largely used to investigate impairments of motor function caused by interference on striatal function. Male Swiss mice received acute pretreatment with CBD (5, 15, 30 or 60 mg/kg, ip) 30 min prior to the D2 receptor antagonist haloperidol (0.6 mg/kg), the non-selective nitric oxide synthase (NOS) inhibitor L-nitro-N-arginine (L-NOARG, 80 mg/kg) or the CB1 receptor agonist WIN55,212-2 (5 mg/kg). The mice were tested 1, 2 or 4 h after haloperidol, L-NOARG or WIN55,212-2 injection. These drugs significantly increased catalepsy time and this effect was attenuated dose-dependently by CBD. CBD, by itself, did not induce catalepsy. In a second set of experiments the mechanism of CBD effects was investigated. Thirty minutes before CBD (30 mg/kg) the animals received the 5-HT1A receptor antagonist WAY100635 (0.1 mg/kg). The anticataleptic effect of CBD was prevented by WAY100635. These findings indicate that CBD can attenuate catalepsy caused by different mechanisms (D2 blockade, NOS inhibition and CB1 agonism) via 5-HT1A receptor activation, suggesting that it could be useful in the treatment of striatal disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 46, 1 October 2013, Pages 43-47
نویسندگان
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