Transcranial direct current stimulation for the treatment of major depressive disorder: A summary of preclinical, clinical and translational findings

► tDCS is a novel brain stimulation tool increasingly used in neuropsychiatry. ► tDCS is based on polarity-effects of DCs in changing cortical excitability. ► Advantages of tDCS are: portability, easiness of use and low rate of side effects. ► tDCS clinical trials in depression have shown promising results. ► We update the main findings and challenges of tDCS as a treatment for depression.