Effect of ACEA-a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model

► ACEA enhances the protective action of ETS, PB and VPA against PTZ-induced seizures. ► ACEA elevates free plasma and total brain concentrations of ETS and VPA. ► ACEA has no impact on free plasma and total brain concentrations of CZP and PB.