کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5845252 1128046 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of comorbid anxiety disorder on neuropsychological function in bipolar II disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
The effect of comorbid anxiety disorder on neuropsychological function in bipolar II disorder
چکیده انگلیسی

ObjectivesBipolar disorder (BP) is often comorbid with anxiety disorder (ANX), especially in bipolar II disorder (BP-II). BP patients with comorbid ANX often manifest intensified symptoms and harmful dysfunctions. However, most studies have focused on bipolar I disorder (BP-I); few have investigated the effect of comorbid ANX on the neuropsychological function of BP-II patients. We examined neuropsychological functions in BP-II patients with and without comorbid ANX.MethodsFifty-nine participants were recruited: 20 patients with interepisode (symptom-free) BP-II without comorbid ANX, 20 with interepisode BP-II with comorbid ANX, and 19 healthy controls. All participants were screened using the Chinese version of the Modified Schedule of Affective Disorder and Schizophrenia-Lifetime (SADS-L). Individuals comorbid with major or minor mental illness other than BP-II were excluded. Comparisons were made between the three groups using neuropsychological tests to assess memory, attention, psychomotor speed, and frontal executive function.ResultsBP-II patients with comorbid ANX showed poorer neuropsychological functions than those in the BP-II-only and control groups. Additionally, BP-II-only patients and controls showed equal cognitive performance.ConclusionsBecause BP-II patients with comorbid ANX had the lowest scores in the majority of neuropsychological functional tests, we conclude that they have greater cognitive impairments than do BP-II patients without comorbid ANX. Neuropsychological dysfunctions seemed more strongly associated with ANX than with BP-II in interepisode periods. Identifying and managing ANX comorbidity is critical when treating BP-II patients.

► BP-II patients and controls demonstrated equal cognitive performance. ► Greater cognitive impairments were found in BP-II with anxiety. ► Important role of Anxiety disorders comorbided in bipolar patients. ► Identifying and managing comorbid ANX is critical when treating BP-II patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 35, Issue 8, 1 December 2011, Pages 1841-1845
نویسندگان
, , , , , , , , , , , ,