کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5845403 1128049 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increasing the density of the D2L receptor and manipulating the receptor environment are required to evidence the partial agonist properties of aripiprazole
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Increasing the density of the D2L receptor and manipulating the receptor environment are required to evidence the partial agonist properties of aripiprazole
چکیده انگلیسی
► We constructed an inducible cell model for the expression of the D2L receptor. ► The response to partial D2 agonists was examined on various receptor densities. ► Increasing receptor density was not sufficient to detect a response to aripiprazole. ► Modifying ionic environment was necessary to measure a response to aripiprazole. ► Such modifications could unravel the functional selective profile of aripiprazole.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 36, Issue 1, 10 January 2012, Pages 60-70
نویسندگان
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