The interplay of cannabinoid and NMDA glutamate receptor systems in humans: Preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects

►Functional interaction (FI) between glutamate and cannabidiol (CBD) receptors contributes to the etiology of schizophrenia. ►It is important to understand the mechanism of action related to the FI of ketamine and CBD in humans. ►Investigating the FI of CBD and ketamine in humans may further clarify the interplay of CB1/2 and NMDA receptors. ►Study shows that a complex FI between CBD and ketamine exists. ►Understanding such FI may lead to new pharmacotherapy for schizophrenia.