Cough, asthma, and cysteinyl-leukotrienes

LTRAs must theoretically be effective against cough of asthmatic subjects through its “anti-asthma” effects, while evidence supporting direct antitussive effects of cys-LTs on “cough receptors” is scarce. An important clinical question is that whether LTRAs involve non-specific antitussive effects. While a definite answer is not available yet, this possibility seems unlikely at the moment, although some secondary anti-inflammatory properties have been reported for montelukast. This issue needs to be clarified by future research to avoid overuse of this expensive class of medication.