کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5846218 | 1128462 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A:diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver
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کلمات کلیدی
IRSliver pyruvate kinaseTNFMGATacyl-CoA oxidaseMTTPDGATSREBPChREBPNEFAstearoyl-CoA desaturaseACCPPARALTMCPSBPSCDCPTFASACOAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازacetyl-CoA carboxylase - استیل کروکسی سیلازfatty acid synthase - اسید چرب سنتازnon-esterified fatty acids - اسیدهای چرب غیر استرادیدهinsulin receptor substrate - انسولین بستر گیرندهWAT, White adipose tissue - بافت چربی سفید، بافت ادیپوز سفیدSteatosis - تغییر چرب یا استئاتوز Spontaneously Hypertensive Rat - خودآزمایی موش بالینیShr - شریtumor necrosis factor - فاکتور نکروز تومورFructose - فروکتوز systolic blood pressure - فشار خون سیستولیکMangiferin - منگیفرینmonocyte chemotactic protein - پروتئین chemotactic monocytecarbohydrate response element binding protein - پروتئین اتصال دهنده عنصر پاسخ کربوهیدراتSterol regulatory element-binding protein - پروتئین اتصال دهنده پروتئین Sterol Regulatorymicrosomal triglyceride transfer protein - پروتئین انتقال تری گلیسرید میکروسمالیWAT - چیCarnitine palmitoyltransferase - کارنتین پالمیتیل ترانسفرازLiver - کبدinsulin receptor - گیرنده انسولینperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mangiferin, a xanthone glucoside, and its associated traditional herbs have been demonstrated to improve abnormalities of lipid metabolism. However, its underlying mechanisms remain largely unclear. This study investigated the anti-steatotic effect of mangiferin in fructose-fed spontaneously hypertensive rat (SHR)s that have a mutation in sterol regulatory element binding protein (SREBP)-1. The results showed that co-administration of mangiferin (15Â mg/kg, once daily, by oral gavage) over 7Â weeks dramatically diminished fructose-induced increases in hepatic triglyceride content and Oil Red O-stained area in SHRs. However, blood pressure, fructose and chow intakes, white adipose tissue weight and metabolic parameters (plasma concentrations of glucose, insulin, triglyceride, total cholesterol and non-esterified fatty acids) were unaffected by mangiferin treatment. Mechanistically, mangiferin treatment suppressed acyl-coenzyme A:diacylglycerol acyltransferase (DGAT)-2 expression at the mRNA and protein levels in the liver. In contrast, mangiferin treatment was without effect on hepatic mRNA and/or protein expression of SREBP-1/1c, carbohydrate response element binding protein, liver pyruvate kinase, fatty acid synthase, acetyl-CoA carboxylase-1, stearoyl-CoA desaturase-1, DGAT-1, monoacyglycerol acyltransferase-2, microsomal triglyceride transfer protein, peroxisome proliferator-activated receptor-alpha, carnitine palmitoyltransferase-1 and acyl-CoA oxidase. Collectively, our results suggest that mangiferin treatment ameliorates fatty liver in fructose-fed SHRs by inhibiting hepatic DGAT-2 that catalyzes the final step in triglyceride biosynthesis. The anti-steatotic effect of mangiferin may occur independently of the hepatic signals associated with de novo fatty acid synthesis and oxidation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 280, Issue 2, 15 October 2014, Pages 207-215
Journal: Toxicology and Applied Pharmacology - Volume 280, Issue 2, 15 October 2014, Pages 207-215
نویسندگان
Xiaomang Xing, Danyang Li, Dilong Chen, Liang Zhou, Ritsu Chonan, Johji Yamahara, Jianwei Wang, Yuhao Li,