کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5851776 1561786 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective role of phosphatidylcholine against cisplatin-induced renal toxicity and oxidative stress in rats
ترجمه فارسی عنوان
نقش محافظتی فسفاتیدیل کولین در برابر سمیت کلیوی ناشی از سیس پلاتین و استرس اکسیداتیو در موش صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Effect of phosphatidylcholine in cisplatin-induced nephrotoxicity was studied in rat model.
- Cisplatin-induced nephrotoxicity was evaluated by serum BUN, creatinine and oxidative stress markers.
- Phosphatidylcholine ameliorated cisplatin-induced serum BUN, creatinine and oxidative stress increases.
- Phosphatidylcholine may have protective effect against cisplatin-induced nephrotoxicity.

Although cisplatin is widely used in the treatment of cancers, clinical use of cisplatin is limited due to its nephrotoxicity. Pathophysiological mechanism of cisplatin-induced renal toxicity is a complex process and has not been fully understand. Reactive oxygen species (ROS) and oxidative stress have been presumed to be involved in this damage process. Phosphatidylcholine (PC) has antioxidant effect and prevents oxidative stress. Therefore, the present study aimed to investigate potential protective effects of PC on cisplatin-induced renal damage in rat. We examined the protective effects of PC on cisplatin-induced renal damage by assessment of serum creatinine, BUN, lipid peroxidation, total glutathione, glutathione peroxidase activity, catalase activity, superoxide dismutase activity and histophathological changes. PC ameliorated cisplatin-induced increases in serum creatinine, urea and oxidative stress. PC also decreased tubular degeneration and hypertrophy of glomeruli. PC may have a protective effect against cisplatin-induced nephrotoxicity in rats via enhancing antioxidant enzyme activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 58, August 2013, Pages 388-393
نویسندگان
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