کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5854025 1130871 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of exogenous metallothionein against thallium-induced oxidative stress in rat liver
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
پیش نمایش صفحه اول مقاله
Effects of exogenous metallothionein against thallium-induced oxidative stress in rat liver
چکیده انگلیسی

Metallothionein (MT) is a low-molecular weight sulfur-rich protein that plays role in metal homeostasis/detoxification and radical scavenging. The following study investigated the ability of exogenous MT to protect against oxidative damage induced by thallium (TI) in rat liver. Male Wistar rats were divided into four groups; a control and three experimental groups. The control group received physiological saline. Group 1 animals were injected with thallium acetate intraperitoneally (i.p.) at a single dose of LD50 (32 mg/kg). In group 2 and group 3, metallothionein I was administrated once at two different doses (1 or 2.5 mg/kg i.p., respectively) 1 h before TI intoxication. Levels of endogenous antioxidants, oxidative stress markers were measured and histopathological examinations were performed 4 days after TI administration. TI accumulation in liver decreased related to the dose of MT. Mostly all of the alterations in the levels antioxidants restored to normal levels in MT administrated animals. H2O2 levels and lipid peroxidation decreased, integrity of hepatocytes and membranous structures inside the cells were preserved. The toxic effects of TI were modulated in MT administrated animals particularly at the dose of 2.5 mg/kg. These findings suggest an active role of exogenous MT against TI-induced oxidative stress in rat liver.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 48, Issue 3, March 2010, Pages 980-987
نویسندگان
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