Manganese transport via the transferrin mechanism

► Mn3+ can be transported into neuronal cells via the Tf mechanism. ► This transport shows characteristics similar to those of Fe3+ transport via this same mechanism. ► The amount of this transport in the neuronal cells used was much less than transport of the same concentration of Mn2+. ► Because Mn3+ is a strong oxidizing agent, it is transport via the Tf mechanism, could also cause oxidative damage to endosomes.