کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5856224 1131972 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safety evaluation of traces of nickel and chrome in cosmetics: The case of Dead Sea mud
ترجمه فارسی عنوان
ارزیابی ایمنی از آثار نیکل و کروم در لوازم آرایشی: مورد گل دریایی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- We present a risk assessment of nickel and chrome in a popular cosmetic ingredient (Dead Sea mud).
- Calculations for nickel and chrome indicate no toxicological concern for systemic toxicity.
- Skin sensitization is also not to be expected by exposure of normal healthy skin to Dead Sea mud.
- Consumers should be aware of the presence of these metals by warning sensitized persons.

BackgroundMetal impurities such as nickel and chrome are present in natural ingredients-containing cosmetic products. These traces are unavoidable due to the ubiquitous nature of these elements. Dead Sea mud is a popular natural ingredient of cosmetic products in which nickel and chrome residues are likely to occur.ObjectiveTo analyze the potential systemic and local toxicity of Dead Sea mud taking into consideration Dead Sea muds' natural content of nickel and chrome.MethodsThe following endpoints were evaluated: (Regulation No. 1223/20, 21/12/2009) systemic and (SCCS's Notes of Guidance) local toxicity of topical application of Dead Sea mud; health reports during the last five years of commercial marketing of Dead Sea mud.Results and conclusionsFollowing exposure to Dead Sea mud, MoS (margin of safety) calculations for nickel and chrome indicate no toxicological concern for systemic toxicity. Skin sensitization is also not to be expected by exposure of normal healthy skin to Dead Sea mud. Topical application, however, is not recommended for already nickel-or chrome-sensitized persons. As risk assessment of impurities present in cosmetics may be a difficult exercise, the case of Dead Sea mud is taken here as an example of a natural material that may contain traces of unavoidable metals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 73, Issue 3, December 2015, Pages 797-801
نویسندگان
, , , , , , ,