کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5856303 1131973 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
How reliable are crystalline silica dust concentration measurements?
ترجمه فارسی عنوان
اندازه گیری غلظت گرد و غبار کریستالی سیلیس چگونه قابل اعتماد است؟
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- We evaluated commercial laboratories ability to detect crystalline silica at current and proposed regulatory levels.
- There was an overall under reporting of the silica values.
- The reported values show very large variability between laboratories.
- The data indicate that cannot reliably and consistently detect crystalline silica at the proposed regulatory levels.

To determine how reliably commercial laboratories measure crystalline silica concentrations corresponding to OSHA's proposed limits, 105 filters were prepared with known masses of 20, 40, and 80 μg of respirable quartz corresponding to airborne silica concentrations of 25, 50, and 100 μg/m3 and were submitted, in a blind test, to qualified commercial laboratories over a nine month period. Under these test conditions, the reported results indicated a lack of accuracy and precision needed to reliably inform regulatory compliance decisions. This was true even for filters containing only silica, without an interfering matrix. For 36 filters loaded with 20 or more micrograms of silica, the laboratories reported non-detected levels of silica. Inter-laboratory variability in this performance test program was so high that the reported results could not be used to reliably discriminate among filters prepared to reflect 8-h exposures to respirable quartz concentrations of 25, 50 and 100 μg/m3. Moreover, even in intra-laboratory performance, there was so much variability in the reported results that 2-fold variations in exposure concentrations could not be reliably distinguished. Part of the variability and underreporting may result from the sample preparation process. The results of this study suggest that current laboratory methods and practices cannot necessarily be depended on, with high confidence, to support proposed regulatory standards with reliable data.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 73, Issue 1, October 2015, Pages 126-136
نویسندگان
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