کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856353 | 1131973 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In utero arsenic exposure in mice and early life susceptibility to cancer
ترجمه فارسی عنوان
در معرض قرار گرفتن در معرض آرسنیک در موش و حساسیت زودرس به سرطان
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کلمات کلیدی
RCCppbNIEHSiAsNASOECDppmMMAtPAPNDNRCNTPDMAEPA12-O-tetradecanoyl phorbol-13-acetate - 12-O-tetradecanoyl فربول-13-استاتHCC - HCCAdrenal - آدرنالArsenic - آرسنیکInorganic arsenic - آرسنیک معدنیInternational Agency for Research on Cancer - آژانس بین المللی تحقیقات سرطانIARC یا International Agency for Research on Cancer - آژانس بین المللی تحقیقات سرطانEnvironmental Protection Agency - آژانس حفاظت از محیط زیستDES - ازdimethylarsinic acid - اسید دی متیلارسینیکmonomethylarsonic acid - اسید مونومیتیلارسونیکNational Toxicology Program - برنامه سم شناسی ملیIn utero - در دوران جنینیDiethylstilbestrol - دی اتیلستیل بسترولgestational day - روز بارداریpostnatal day - روز پس از زایمانOrganisation for Economic Cooperation and Development - سازمان همکاری اقتصادی و توسعهCancer - سرطانTransplacental carcinogenesis - سرطان زاIntegrated Risk Information System - سیستم اطلاعات ریسک مجتمعNational Research Council - شورای تحقیقات ملیIris - عنبیهPrenatal - قبل از تولدparts per million - قطعات در میلیونparts per billion - قطعات در هر میلیاردNational Institute of Environmental Health Sciences - موسسه ملی علوم بهداشت محیطMice - موشRenal cell carcinoma - کارسینوم سلول کلیوی یا RCC Hepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)Liver - کبد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
In its review of the U.S. Environmental Protection Agency's toxicological review of inorganic arsenic (iAs), the National Academy of Sciences identified carcinogenic endpoints among the highest priority health effects of concern and stated the need to consider evidence that early life exposures may increase the risk of adverse health effects. Recent studies in mice suggest that in utero exposure to arsenic increases susceptibility to cancer later in life. These data are striking in light of the general lack of evidence for carcinogenicity in rodents exposed to iAs. To evaluate the transplacental carcinogenic potential of iAs, a detailed analysis of the toxicology literature evaluating the role of in utero arsenic exposure in carcinogenesis was conducted. Bladder, lung, and skin tumors, which are the tumor types most consistently reported in humans exposed to high arsenic levels, were not consistently increased in mouse studies. There was also a lack of concordance across studies for other tumor types not typically reported in humans. Therefore, we considered methodological and other critical issues that may have contributed to variable results and we suggest additional studies to address these issues. It was concluded that the available data do not provide evidence of a causal link between in utero arsenic exposure and cancer or indicate early life-stage susceptibility to arsenic-induced cancer, particularly at environmentally relevant doses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 73, Issue 1, October 2015, Pages 378-390
Journal: Regulatory Toxicology and Pharmacology - Volume 73, Issue 1, October 2015, Pages 378-390
نویسندگان
Michael R. Garry, Annette B. Santamaria, Amy L. Williams, John M. DeSesso,