کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5856675 1131980 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Do group responses mask the effects of air pollutants on potentially sensitive individuals in controlled human exposure studies?
ترجمه فارسی عنوان
آیا پاسخ گروهی اثرات آلاینده های هوا را در افراد بالقوه حساس در مطالعات مواجهه با انسداد تحت کنترل قرار می دهد؟
کلمات کلیدی
استانداردهای کیفیت هوا در سطح ملی، دی اکسید نیتروژن، ازن، دی اکسید گوگرد، عملکرد ریه، مطالعات مواجهه تحت کنترل، آسم،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
To establish primary National Ambient Air Quality Standards (NAAQS) for criteria air pollutants such as nitrogen dioxide (NO2), ozone (O3), and sulfur dioxide (SO2), US EPA relies in part on controlled human exposure studies. It has been suggested that evaluating average responses for all participants in these studies may not reflect the responses of sensitive participants in these studies. To evaluate this, we identified controlled exposure studies with multiple exposure concentrations or durations that provided individual-level lung function data. Based on individual lung function responses at specific exposure concentrations and the slope of individual concentration-response curves, we identified 12 participants out of a total of 208 participants in 12 studies who were potentially sensitive to O3, SO2, or sulfuric acid (H2SO4). We did not identify any participants sensitive to NO2. All of these participants were found to be potentially sensitive only at concentrations that were well above the NAAQS (SO2), above likely ambient concentrations (H2SO4), or at concentrations at which the study reported significant lung function effects for all participants (O3). Based on our analysis, average responses for all participants combined adequately reflect lung function responses for potentially sensitive study participants at concentrations in the range of the current NAAQS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 71, Issue 3, April 2015, Pages 552-564
نویسندگان
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