کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5856911 1131985 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lowest adverse effects concentrations (LOAECs) for formaldehyde exposure
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Lowest adverse effects concentrations (LOAECs) for formaldehyde exposure
چکیده انگلیسی
In 2012 the Committee for Risk Assessment (RAC) of the European Chemicals Agency concluded that 2 ppm formaldehyde represent a Lowest Observed Adverse Effect Concentration (LOAEC) for polypoid adenomas, histopathological lesions and cell proliferation. An analysis of all data shows that a LOAEC of 2 ppm it is not justified for cell proliferation and polypoid adenomas. Higher values are also supported by a new statistical analysis. For histopathological lesions a NOAEC of 1 ppm may be defined but the lesions at 2 ppm cannot be regarded as pre-stages for tumour development. One major uncertainty exists: the description of polypoid adenomas and the lesions at 2 ppm often is insufficient and diagnostic uncertainties can only be resolved by a re-evaluation according to modern histomorphological standards. Although the discrepancy between our assessment and that of RAC may seem rather small we feel the LOAECs proposed by RAC must be challenged taking into consideration the broad data base for formaldehyde and the potential impact of any published RAC opinion on the present discussions about appropriate occupational and indoor exposure limits.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 70, Issue 1, October 2014, Pages 340-348
نویسندگان
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