Derivation of a chronic reference concentration for decalin

► The critical effect for chronic inhalation exposure to decalin is hepatotoxicity. ► Using a log-logistic model, the point of departure was estimated as 7.9 mg/m3. ► A total uncertainty factor of 100 was utilized to derive a safe human dose. ► A chronic reference concentration of 0.08 mg/m3 was calculated for decalin.