کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856989 | 1131988 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Health assessment of gasoline and fuel oxygenate vapors: Immunotoxicity evaluation
ترجمه فارسی عنوان
ارزیابی سلامت بخارات بنزین و سوخت اکسیژن همراه: ارزیابی ایمنی سمیت
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Female Sprague Dawley rats were exposed via inhalation to vapor condensates of either gasoline or gasoline combined with various fuel oxygenates to assess potential immunotoxicity of evaporative emissions. Test articles included vapor condensates prepared from “baseline gasoline” (BGVC), or gasoline combined with methyl tertiary butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA). Target concentrations were 0, 2000, 10,000 or 20,000Â mg/mg3 administered for 6Â h/day, 5Â days/week for 4Â weeks. The antibody-forming cell (AFC) response to the T-dependent antigen, sheep erythrocyte (sRBC), was used to determine the effects of the gasoline vapor condensates on the humoral components of the immune system. Exposure to BGVC, G/MTBE, G/TAME, and G/TBA did not result in significant changes in the IgM AFC response to sRBC, when evaluated as either specific activity (AFC/106 spleen cells) or as total spleen activity (AFC/spleen). Exposure to G/EtOH and G/DIPE resulted in a dose-dependent decrease in the AFC response, reaching the level of statistical significance only at the high 20,000Â mg/m3 level. Exposure to G/ETBE resulted in a statistically significant decrease in the AFC response at the middle (10,000Â mg/m3) and high (20,000Â mg/m3) exposure concentrations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 70, Issue 2, Supplement, 1 November 2014, Pages S43-S47
Journal: Regulatory Toxicology and Pharmacology - Volume 70, Issue 2, Supplement, 1 November 2014, Pages S43-S47
نویسندگان
Kimber L. Jr., Vanessa L. Peachee, Sarah R. Armstrong, Lorraine E. Twerdok, Charles R. Clark, Ceinwen A. Schreiner,