کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5857250 | 1131997 | 2012 | 9 صفحه PDF | دانلود رایگان |
Recently, the fruits of Hylocereus polyrhizus, known as red dragon fruit, have received much attention from growers worldwide. However, there is little toxicological information regarding the safety of repeated exposure to these fruits. The present study evaluated the potential toxicity of a methanol extract of H. polyrhizus fruit after acute and subchronic administration in rats. In the acute toxicity study, single doses of fruit extract (1250, 2500 and 5000Â mg/kg) were administered to rats by oral gavage, and the rats were then monitored for 14Â days. In the subchronic toxicity study, the fruit extract was administered orally to rats at doses of 1250, 2500 and 5000Â mg/kg/day for 28Â days. There was no mortality or signs of acute or subchronic toxicity. There was no significant difference in body weight, relative organ weight or hematological parameters in the subchronic toxicity study. Biochemical analysis showed some significant changes, including creatinine, globulin, total protein and urea levels. No abnormality of internal organs was observed between treatment and control groups. The lethal oral dose of the fruit extract is more than 5000Â mg/kg and the no-observed-adverse-effect level (NOAEL) of the extract for both male and female rats is considered to be 5000Â mg/kg per day for 28Â days.
⺠Acute and 28-day subchronic studies were conducted in Sprague-Dawley rats. ⺠Lethal oral dose of Hylocereus polyrhizus fruits extract for rats is more than 5000 mg/kg. ⺠Oral dosage of H. polyrhizus fruits extract to rat did not show signs of toxicity.
Journal: Regulatory Toxicology and Pharmacology - Volume 63, Issue 1, June 2012, Pages 106-114