کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5857294 1131998 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epidemiologic studies of glyphosate and cancer: A review
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Epidemiologic studies of glyphosate and cancer: A review
چکیده انگلیسی

The United States Environmental Protection Agency and other regulatory agencies around the world have registered glyphosate as a broad-spectrum herbicide for use on multiple food and non-food use crops. Glyphosate is widely considered by regulatory authorities and scientific bodies to have no carcinogenic potential, based primarily on results of carcinogenicity studies of rats and mice. To examine potential cancer risks in humans, we reviewed the epidemiologic literature to evaluate whether exposure to glyphosate is associated causally with cancer risk in humans. We also reviewed relevant methodological and biomonitoring studies of glyphosate. Seven cohort studies and fourteen case-control studies examined the association between glyphosate and one or more cancer outcomes. Our review found no consistent pattern of positive associations indicating a causal relationship between total cancer (in adults or children) or any site-specific cancer and exposure to glyphosate. Data from biomonitoring studies underscore the importance of exposure assessment in epidemiologic studies, and indicate that studies should incorporate not only duration and frequency of pesticide use, but also type of pesticide formulation. Because generic exposure assessments likely lead to exposure misclassification, it is recommended that exposure algorithms be validated with biomonitoring data.

► We reviewed epidemiologic studies of glyphosate and cancer outcomes. ► We identified seven cohort studies and fourteen case-control studies. ► Our review found no consistent pattern of positive associations with any cancer. ► We recommend that exposure algorithms be validated with biomonitoring data.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 63, Issue 3, August 2012, Pages 440-452
نویسندگان
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