کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5857435 1132007 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Are we in the dark ages of environmental toxicology?
ترجمه فارسی عنوان
آیا ما در سنین پیری سم شناسی محیط زیست هستیم؟
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Environmental toxicity is judged to be in a “dark ages” period due to longstanding limitations in the implementation of the simple conceptual model that is the basis of current aquatic toxicity testing protocols. Fortunately, the environmental regulatory revolution of the last half-century is not substantially compromised as development of past regulatory guidance was designed to deal with limited amounts of relatively poor quality toxicity data. However, as regulatory objectives have substantially increased in breadth and depth, aquatic toxicity data derived with old testing methods are no longer adequate. In the near-term explicit model description and routine assumption validation should be mandatory. Updated testing methods could provide some improvements in toxicological data quality. A thorough reevaluation of toxicity testing objectives and methods resulting in substantially revised standard testing methods, plus a comprehensive scheme for classification of modes/mechanisms of toxic action, should be the long-term objective.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 67, Issue 3, December 2013, Pages 321-324
نویسندگان
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