کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5857933 | 1562154 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamic expression of corticotropin-releasing hormone and urocortin in estrogen induced-cholestasis pregnant rat
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کلمات کلیدی
CRHICPUCNALTIUFDAST - آسپارتات ترانس آمینازalanine transaminase - آلانین ترانس آمینازEthinylestradiol - اتینیلسترایدیولUrocortin - اوروکورتینaspartate transaminase - ترانس آمیناز آسپارتاتPlacenta - جفت Intrauterine fetal death - مرگ جنینی داخل رحمیRegulation - مقرراتRat - موش صحراییcorticotropin-releasing hormone - هورمون آزاد کننده کورتیکوتروپینPathogenesis - پاتونزcholestasis - کلستاز Intrahepatic cholestasis of pregnancy - کلستاز داخل شکمی بارداری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dynamic expression of corticotropin-releasing hormone and urocortin in estrogen induced-cholestasis pregnant rat Dynamic expression of corticotropin-releasing hormone and urocortin in estrogen induced-cholestasis pregnant rat](/preview/png/5857933.png)
چکیده انگلیسی
Intrahepatic cholestasis of pregnancy(ICP) is complicated by acute placental-fetal hypoxia. Corticotropin-releasing hormone(CRH) and urocortin(UCN) are vasodilatory regulators of blood flow in the placenta. An ethinylestradiol(EE)-induced cholestasis rat model was reproduced and serum/placental CRH/UCN were detected during 14-21Â days of gestation(DG). Maternal serum or placental CRH/UCN levels in the control rats were relatively consistent during 14-21DG. Serum CRH was reduced in the EE-treated rats compared with the control rats at 21DG. Regarding serum UCN, we observed a decrease at 17DG as well as an increase at 21DG in the EE-treated rats compared with the controls. Moreover, we observed a noticeable reduction of placental CRH/UCN expression at 17 or 19DG in the EE-treated rats compared with the control rats. The serum bile acids levels exhibited an inverse correlation with placental CRH/UCN expression. EE-induced cholestasis rats might serve as a good model to further investigate the pathological mechanism underlying CRH/UCN dysregulation in ICP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 65, October 2016, Pages 179-186
Journal: Reproductive Toxicology - Volume 65, October 2016, Pages 179-186
نویسندگان
Fan Zhou, Bingxin Gao, Chunyan Deng, Guiqiong Huang, Ting Xu, Xiaodong Wang,