کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5857951 | 1562154 | 2016 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of long-term endocrine disrupting compound exposure on Macaca mulatta embryonic stem cells
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کلمات کلیدی
BPAEDCATRDEHPIPAdi-(2-ethylhexyl) phthalate - di- (2-اتیل هگزیل) فتالاتatrazine - آترازینBisphenol A - بیسفنول ای، بیسفنول AESC - خروجEmbryonic stem cell - سلول های بنیادی جنینیDEG - شماendocrine disrupting chemical - شیمیایی خرابکار غدد درون ریزCanonical pathway - مسیر کانونیکالDifferentially expressed gene - ژن بیان شده متفاوت است
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Endocrine disrupting chemicals (EDCs) exert significant effects on health and physiology, many traceable to effects on stem cell programming underlying development. Understanding risk of low-level, chronic EDC exposure will be enhanced by knowledge of effects on stem cells. We exposed rhesus monkey embryonic stem cells to low levels of five EDCs [bisphenol A (BPA), atrazine (ATR), tributyltin (TBT), perfluorooctanoic acid (PFOA), and di-(2-ethylhexyl) phthalate (DEHP)] for 28 days, and evaluated effects on gene expression by RNAseq transcriptome profiling. We observed little effect of BPA, and small numbers of affected genes (â¤119) with other EDCs. There was substantial overlap in effects across two, three, or four treatments. Ingenuity Pathway analysis indicated suppression of cell survival genes and genes downstream of several stress response mediators, activation of cell death genes, and modulations in several genes regulating pluripotency, differentiation, and germ layer development. Potential adverse effects of these changes on development are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 65, October 2016, Pages 382-393
Journal: Reproductive Toxicology - Volume 65, October 2016, Pages 382-393
نویسندگان
Uros Midic, Kailey A. Vincent, Catherine A. VandeVoort, Keith E. Latham,