کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5858074 | 1562161 | 2015 | 5 صفحه PDF | دانلود رایگان |
- Bisphenol A (BPA) enhanced growth rate and clonogenic ability of RL95-2 cells in dose responsive manner.
- BPA induced epithelial-mesenchymal transition (EMT) through cyclooxygenase-2 (COX-2) mediated mechanism.
- BPA increased cell migration and invasion ability through MAPK pathway-dependent up-regulation of COX-2 expression.
Many studies have highlighted the correlation between the increase of bisphenol A (BPA) level in the environment and the incidence of tumor in humans. In human carcinogenesis, the overexpression of cyclooxygenase-2 (COX-2) and epithelial-mesenchymal transition (EMT) are closely related with tumor development. In this study, human endometrial carcinoma cells line (RL95-2) was used to investigate whether BPA can induce EMT and COX-2 expression. The results show that BPA increased growth rate and colony-forming efficiency in a dose-dependent manner, induced EMT and COX-2 gene expression and promoted the migration and invasion ability of RL95-2 cells. Furthermore, our study showed that the expression of COX-2 was essential for BPA-induced cell migration and invasion. The results of this study provide new insights into the mechanism of endometrial cancer cell growth and invasion and potential therapeutic strategy.
Journal: Reproductive Toxicology - Volume 58, December 2015, Pages 229-233