کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5858122 | 1562160 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quaternary ammonium disinfectants cause subfertility in mice by targeting both male and female reproductive processes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC) are common ingredients in household bathroom and kitchen cleaning sprays. ADBACÂ +Â DDAC cause reproductive toxicity in mice. The aim of the present study was to investigate gender-specific reproductive effects from ADBACÂ +Â DDAC. Female reproduction was assessed through ovulation, oocyte implantation, and estrus cycling. Male reproductive function was assessed by sperm concentration, motility, and viability. Numbers of corpora lutea were not different after 2 weeks, but decreased after 8 weeks of ADBACÂ +Â DDAC exposure. Dams exposed for 5 weeks to ADBACÂ +Â DDAC spent significantly less time in estrus. ADBACÂ +Â DDAC exposed males exhibited declines in both sperm concentration and motility, but not sperm viability. Subfertility in mice from ADBACÂ +Â DDAC exposure is, therefore, mediated through reproductive disturbances in both females and males. While the effect of ADBACÂ +Â DDAC exposure on human health is unclear, widespread exposure necessitates further consideration of their potential reproductive toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 59, January 2016, Pages 159-166
Journal: Reproductive Toxicology - Volume 59, January 2016, Pages 159-166
نویسندگان
Vanessa E. Melin, Travis E. Melin, Brian J. Dessify, Christina T. Nguyen, Caroline S. Shea, Terry C. Hrubec,