کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5858823 1562170 2014 42 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Assessment of estrogenic potential of diethyl phthalate in female reproductive system involving both genomic and non-genomic actions
ترجمه فارسی عنوان
ارزیابی پتانسیل استروژن رژیم فتالات در سیستم تولید مثل زنانه شامل هر دو اقدام ژنومی و غیر ژنومی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Phthalates are the diverse group of compounds abundantly present in environment. The present study shows the estrogenic potential of diethyl phthalate (DEP). The data showed that DEP increased the transactivation of ER in CHO and MCF-7 cells suggesting its interaction with ER. In vivo parameters like increased uterine epithelial cell height and up regulation of various steroidogenic genes were also observed in adult female rats. Our uterotrophic assay data from immature female rats suggested that DEP treatment resulted in augmentation of uterine weight as well as luminal epithelial cell heights in both vaginal and uterine tissues. Further, DEP was able to upregulate pS2 gene expression with simultaneous activation of MAPK pathway as demonstrated by increased p-ERK/ERK ratio. Taken together, the present data suggests that DEP acts as an estrogenic compound and based on these data further detailed studies would reveal its mode of action at cellular levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 49, November 2014, Pages 12-26
نویسندگان
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