کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5859742 1562615 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationConstruction of local gene network for revealing different liver function of rats fed deep-fried oil with or without resistant starch
ترجمه فارسی عنوان
ارتباط کوتاه ساختن شبکه ژن محلی برای نشان دادن عملکرد کبدی مختلف در موش های صحرایی با روغن سرخ شده سرخ شده با نشاسته مقاوم یا بدون آن
کلمات کلیدی
روغن سرخ شده عمیق نشاسته مقاوم شبکه ژن، مسیر سیگنالینگ،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Up/down regulated genes and corresponding signaling pathways were used to construct LGN.
- Changes in genes induced by DO led to a larger probability of disease or infection.
- Signaling pathways of rats were almost the same between DO-containing diet and DO-RS diet.
- RS in DO-containing diet may mainly regulate the genes that related to DO damage.

To study the mechanism underlying the liver damage induced by deep-fried oil (DO) consumption and the beneficial effects from resistant starch (RS) supplement, differential gene expression and pathway network were analyzed based on RNA sequencing data from rats. The up/down regulated genes and corresponding signaling pathways were used to construct a novel local gene network (LGN). The topology of the network showed characteristics of small-world network, with some pathways demonstrating a high degree. Some changes in genes led to a larger probability occurrence of disease or infection with DO intake. More importantly, the main pathways were found to be almost the same between the two LGNs (30 pathways overlapped in total 48) with gene expression profile. This finding may indicate that RS supplement in DO-containing diet may mainly regulate the genes that related to DO damage, and RS in the diet may provide direct signals to the liver cells and modulate its effect through a network involving complex gene regulatory events. It is the first attempt to reveal the mechanism of the attenuation of liver dysfunction from RS supplement in the DO-containing diet using differential gene expression and pathway network.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 258, 6 September 2016, Pages 168-174
نویسندگان
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