کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5860112 1133165 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A guidance value of 1-hydroxypyrene in urine in view of acceptable occupational exposure to polycyclic aromatic hydrocarbons
ترجمه فارسی عنوان
مقدار هدایت 1-هیدروکسیپیرن در ادرار با توجه به مواجه شغلی قابل قبول با هیدروکربن های آروماتیک چند حلقه ای
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
In order to assess the point-of-departure for limit setting, cross-sectional studies were searched for that report on the response of early genotoxic effects in white blood cells of workers that could be related to the degree of PAH-exposure (expressed as 1-hydroxypyrene in urine). Nine cross-sectional studies were traced that met these requirements. From each study, the concentration of 1-hydroxypyrene in end-of-shift urine samples was determined, at which no genotoxic effects was found. From 4 out of 9 studies a no-observed genotoxic effect level could be derived, the lowest level was 1.0 μmol/mol creatinine. This limit level is recommended as a state-of-the-art guidance, valid when the PAH-profile in the work environment is similar to that of coke oven with a typical pyrene/BaP ratio of 2.5. For work environments with a deviating PAH-profile an adjustment procedure with the pyrene/BaP ratio is suggested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 231, Issue 2, 1 December 2014, Pages 239-248
نویسندگان
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