کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5860171 | 1133169 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells
ترجمه فارسی عنوان
فعالیت ضد انعقادی عصاره های پلی فنولی از ساقه انگور در برابر سلول های سرطانی، کولون، کلیوی و تیروئید
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کلمات کلیدی
TCATPCPARPROS - ROSAIF - آیفونtrichloroacetic acid - اسید ترشکلراکتیکapoptosis-inducing factor - عامل القاء آپوپتوزAnticancer activity - فعالیت ضد سرطانTotal polyphenolic content - محتوای کل پلی فنلpoly-ADP-ribose polymerase - پلی-ADP-ریبوز پلیمرازPolyphenols - پلیفنلهاReactive oxygen species - گونههای فعال اکسیژنVitis vinifera - گیاه انگور، مو
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
A major part of the wineries' wastes is composed of grape stems which are discarded mainly in open fields and cause environmental problems due mainly to their high polyphenolic content. The grape stem extracts' use as a source of high added value polyphenols presents great interest because this combines a profitable venture with environmental protection close to wine-producing zones. In the present study, at first, the Total Polyphenolic Content (TPC) and the polyphenolic composition of grape stem extracts from four different Greek Vitis vinifera varieties were determined by HPLC methods. Afterwards, the grape stem extracts were examined for their ability to inhibit growth of colon (HT29), breast (MCF-7 and MDA-MB-23), renal (786-0 and Caki-1) and thyroid (K1) cancer cells. The cancer cells were exposed to the extracts for 72 h and the effects on cell growth were evaluated using the SRB assay. The results indicated that all extracts inhibited cell proliferation, with IC50 values of 121-230 μg/ml (MCF-7), 121-184 μg/ml (MDA-MD-23), 175-309 μg/ml (HT29), 159-314 μg/ml (K1), 180-225 μg/ml (786-0) and 134->400 μg/ml (Caki-1). This is the first study presenting the inhibitory activity of grape stem extracts against growth of colon, breast, renal and thyroid cancer cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 230, Issue 2, 15 October 2014, Pages 218-224
Journal: Toxicology Letters - Volume 230, Issue 2, 15 October 2014, Pages 218-224
نویسندگان
Despina Sahpazidou, George D. Geromichalos, Dimitrios Stagos, Anna Apostolou, Serkos A. Haroutounian, Aristidis M. Tsatsakis, George N. Tzanakakis, A. Wallace Hayes, Dimitrios Kouretas,