The effect of tributyltin chloride on Caenorhabditis elegans germline is mediated by a conserved DNA damage checkpoint pathway

- We used Caenorhabditis elegans to investigate how TBTCL exhibits its effect on animal germline.
- TBTCL exposure resulted in increased sterility and embryonic lethality.
- TBTCL exposure induced increased DSBs and checkpoint activation in germline.
- Germ cell apoptosis and proliferation arrest were induced by TBTCL exposure.
- Checkpoint and p53 signaling pathways were found essential in response to TBTCL.