کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5860470 | 1133187 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Short term inhalation toxicity of a liquid aerosol of glutaraldehyde-coated CdS/Cd(OH)2 core shell quantum dots in rats
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کلمات کلیدی
MMADSMPSGSDInhalation - استنشاقgeometric standard deviation - انحراف استاندارد هندسیTem - این استBALF - بافتScanning mobility particle sizer - دانسیته ذرات حرکتی اسکن شدهICP-MS - طیفسنجی جرمی پلاسمای جفتشده القاییinductively coupled plasma mass spectrometry - طیفسنجی جرمی پلاسمای جفتشده القاییMass median aerodynamic diameter - قطر آیرودینامیکی متوسط Medianbroncho-alveolar lavage fluid - مایع شستشوی برونکو-آلوئولارSub-acute toxicity - مسمومیت حادRat - موش صحراییTransmission electron microscopy - میکروسکوپ الکترونی عبوریquantum dots - نقاط کوانتومیCadmium - کادمیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Quantum dots exhibit extraordinary optical and mechanical properties, and the number of their applications is increasing. In order to investigate a possible effect of coating on the inhalation toxicity of previously tested non-coated CdS/Cd(OH)2 quantum dots and translocation of these very small particles from the lungs, rats were exposed to coated quantum dots or CdCl2 aerosol (since Cd2+ was present as impurity), 6Â h/d for 5 consecutive days. Cd content was determined in organs and excreta after the end of exposure and three weeks thereafter. Toxicity was determined by examination of broncho-alveolar lavage fluid and microscopic evaluation of the entire respiratory tract. There was no evidence for translocation of particles from the respiratory tract. Evidence of a minimal inflammatory process was observed by examination of broncho-alveolar lavage fluid. Microscopically, minimal to mild epithelial alteration was seen in the larynx. The effects observed with coated quantum dots, non-coated quantum dots and CdCl2 were comparable, indicating that quantum dots elicited no significant effects beyond the toxicity of the Cd2+ ion itself. Compared to other compounds with larger particle size tested at similarly low concentrations, quantum dots caused much less pronounced toxicological effects. Therefore, the present data show that small particle sizes with corresponding high surfaces are not the only factor triggering the toxic response or translocation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 225, Issue 1, 10 February 2014, Pages 20-26
Journal: Toxicology Letters - Volume 225, Issue 1, 10 February 2014, Pages 20-26
نویسندگان
L. Ma-Hock, P.M.A. Farias, T. Hofmann, A.C.D.S. Andrade, J.N. Silva, T.M.S. Arnaud, W. Wohlleben, V. Strauss, S. Treumann, C.R. Chaves, S. Gröters, R. Landsiedel, B. van Ravenzwaay,