کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5860521 | 1133189 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Deoxynivalenol-induced weight loss in the diet-induced obese mouse is reversible and PKR-independent
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کلمات کلیدی
CCKSOCS3LFDPYYDIOIL-1βDeoxynivalenolIL-6interleukin-6 - اینترلوکین ۶Interleukin-1β - اینترلوکین-1βanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceDON - دونLow fat diet - رژیم غذایی کم چربیsuppressor of cytokine signaling 3 - سرکوب سیگنالینگ سیتوکین 3peptide YY - پپتید YYdiet-induced obese - چاقی ناشی از رژیم غذایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Deoxynivalenol-induced weight loss in the diet-induced obese mouse is reversible and PKR-independent Deoxynivalenol-induced weight loss in the diet-induced obese mouse is reversible and PKR-independent](/preview/png/5860521.png)
چکیده انگلیسی
The trichothecene deoxynivalenol (DON), a potent ribotoxic mycotoxin produced by the cereal blight fungus Fusarium graminearum, commonly contaminates grain-based foods. Oral exposure to DON causes decreased food intake, reduced weight gain and body weight loss in experimental animals - effects that have been linked to dysregulation of hormones responsible for mediating satiety at the central nervous system level. When diet-induced obese (DIO) mice are fed DON, they consume less food, eventually achieving body weights of control diet-fed mice. Here, we extended these findings by characterizing: (1) reversibility of DON-induced body weight loss and anorexia in DIO mice and (2) the role of double-stranded RNA-activated protein kinase (PKR) which has been previously linked to initiation of the ribotoxic stress response. The results demonstrated that DON-induced weight loss was reversible in DIO mice and this effect corresponded to initiation of a robust hyperphagic response. When DIO mice deficient in PKR were exposed to DON, they exhibited weight suppression similar to DIO wild-type fed the toxin, suggesting the toxin's weight effects were not dependent on PKR. Taken together, DON's effects on food consumption and body weight are not permanent and, furthermore, PKR is not an essential signaling molecule for DON's anorectic and weight effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 221, Issue 1, 31 July 2013, Pages 9-14
Journal: Toxicology Letters - Volume 221, Issue 1, 31 July 2013, Pages 9-14
نویسندگان
Brenna M. Flannery, Kaiyu He, James J. Pestka,