GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin

- Wogonin inhibited C6 cells growth and arrested at G0/G1 phase of the cell cycle.
- Wogonin induced typical morphological changes and an increase in GFAP level.
- Induction of cell differentiation by wogonin ascribed to the restrain of GSK-3β/β-catenin pathway.
- Blocking GSK-3β/β-catenin signaling promotes the glial differentiation of glioma cells.